Cardiovascular Safety in Drug Development and Therapeutic Use (Post nr. 1198)

MARC-detaljer
000 -LEADER
fixed length control field	03787nam a22004575i 4500
001 - CONTROL NUMBER
control field	60030
005 - DATE AND TIME OF LATEST TRANSACTION
control field	20200226102305.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field	cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field	160728s2017 gw \| s \|\|\|\| 0\|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number	9783319403472
--	978-3-319-40347-2
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code	10.1007/978-3-319-40347-2
Source of number or code	doi
035 ## - SYSTEM CONTROL NUMBER
System control number	(DE-He213)978-3-319-40347-2
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number	RS1-441
072 #7 - SUBJECT CATEGORY CODE
Subject category code	MMG
Source	bicssc
072 #7 - SUBJECT CATEGORY CODE
Subject category code	MED071000
Source	bisacsh
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number	353.998
Edition number	23
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name	Turner, J. Rick.
Relator term	author.
245 10 - TITLE STATEMENT
Title	Cardiovascular Safety in Drug Development and Therapeutic Use
Medium	[electronic resource] :
Remainder of title	New Methodologies and Evolving Regulatory Landscapes /
Statement of responsibility, etc.	by J. Rick Turner, Dilip R. Karnad, Snehal Kothari.
264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Place of production, publication, distribution, manufacture	Cham :
Name of producer, publisher, distributor, manufacturer	Springer International Publishing :
--	Imprint: Adis,
Date of production, publication, distribution, manufacture, or copyright notice	2017.
300 ## - PHYSICAL DESCRIPTION
Extent	XXVI, 333 p. 2 illus. in color.
Other physical details	online resource.
336 ## - CONTENT TYPE
Content type term	text
Content type code	txt
Source	rdacontent
337 ## - MEDIA TYPE
Media type term	computer
Media type code	c
Source	rdamedia
338 ## - CARRIER TYPE
Carrier type term	online resource
Carrier type code	cr
Source	rdacarrier
347 ## - DIGITAL FILE CHARACTERISTICS
File type	text file
Encoding format	PDF
Source	rda
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note	The Central Importance of Cardiovascular Safety in Contemporary New Drug Development -- The Biological Basis of Drug Responses -- Cardiovascular Structure, Function, Pathophysiology, & Disease -- The Current Regulatory Landscape -- The "Comprehensive In Vitro Proarrhythmia Assay" Initiative -- The "Early ECG Assessment" Initiative -- The "Submission of Extended Digital ECG Data" Initiative -- Meta-analysis and Meta-methodology -- Current Regulatory Landscapes and their Potential Evolution -- Off-target Blood Pressure Responses to Non-cardiovascular Drugs -- Oncology Drug Development and Therapeutics: Cardiotoxicity Considerations -- Postmarketing Surveillance -- Regulatory Perspectives on General Drug Safety -- Future Directions in Cardiovascular Safety -- References.
520 ## - SUMMARY, ETC.
Summary, etc.	With the advent of multiple new therapeutic agents for a variety of important diseases has come an increasing realization that many of these drugs can have adverse effects on the heart and vascular system. As this book so elegantly details the mechanisms by which harm occurs are highly complex, many times predictable, but always clinically relevant. Notable experts in the field of cardiovascular medicine, such as Drs. Turner, Karnad, and Kothari, have turned their attention to this thorny problem, and begun to dissect the diverse mechanisms by which cardiac harm can occur with a variety of non-cardiac drugs. This is no easy task, given the complexity of the diseases we treat, and the wide spectrum of new therapies we seek to apply. However, it is an issue with which all health care providers must become familiar in order to prescribe appropriate therapy while safeguarding patients against avoidable and life-threatening cardiac adverse effects. This compendium represents the state-of-the-art in the evolving field of cardiac safety and is vital reading for those interested in developing new chemical entities, as well as those who prescribe them and monitor patients for their hazard. As such, I recommend this book as essential reading for students, scientists, and health care providers at all levels of training. Peter R. Kowey, MD, FACC, FAHA, FHRS Lankenau Institute for Medical Research & Thomas Jefferson University.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element	Medicine.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element	Cardiology.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element	Pharmacy.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element	Medicine & Public Health.
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element	Drug Safety and Pharmacovigilance.
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element	Cardiology.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name	Karnad, Dilip R.
Relator term	author.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name	Kothari, Snehal.
Relator term	author.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element	SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title	Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Relationship information	Printed edition:
International Standard Book Number	9783319403458
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier	<a href="http://dx.doi.org/10.1007/978-3-319-40347-2">http://dx.doi.org/10.1007/978-3-319-40347-2</a>
912 ## -
--	ZDB-2-SME

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