TY - BOOK AU - Chu,Cong-Qiu ED - SpringerLink (Online service) TI - Targeting the IL-17 Pathway in Inflammatory Disorders SN - 9783319280400 AV - RC927-927.5 U1 - 616.723 23 PY - 2017/// CY - Cham PB - Springer International Publishing, Imprint: Adis KW - Medicine KW - Dermatology KW - Public health KW - Rheumatology KW - Primary care (Medicine) KW - Pharmacotherapy KW - Medicine & Public Health KW - Primary Care Medicine N1 - Introduction -- Overview of IL-17 family.-Il-17 in host defense -- Th17 cells: differentiation and regulation -- The role of the IL-17/Th17 pathway in the pathogenesis of autoimmune inflammatory diseases -- Therapeutic applications: strategies and molecules targeting the IL-17/Th17 pathway -- Concluding remarks N2 - This book provides an overview of the discovery and structure of IL-17, including its pathogenesis and role in chronic inflammation and autoimmunity. To capture the latest developments and product approvals the book also discusses the therapeutic advances and looks at emerging therapies targeting the IL-17 pathway. IL-17 is a pro-inflammatory cytokine that has a key role in inflammation, autoimmunity, and host defense in a number of inflammatory disorders such as rheumatoid arthritis, psoriatic arthritis and psoriasis, ankylosing spondylitis, multiple sclerosis, and inflammatory bowel disease. The discovery of the IL-17-Th17 pathway has seen exciting development in the field of immunology and inflammation research, which has led to a number of recent regulatory approvals UR - http://dx.doi.org/10.1007/978-3-319-28040-0 ER -