000			03789nam a22005775i 4500
001			60082
005			20200226102300.0
007			cr nn 008mamaa
008			161107s2017 gw | s |||| 0|eng d
020			_a9783319423272 _9978-3-319-42327-2
024	7		_a10.1007/978-3-319-42327-2 _2doi
035			_a(DE-He213)978-3-319-42327-2
050		4	_aRC254-282
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a616.994 _223
245	1	0	_aBone Metastases from Prostate Cancer _h[electronic resource] : _bBiology, Diagnosis and Management / _cedited by Francesco Bertoldo, Francesco Boccardo, Emilio Bombardieri, Laura Evangelista, Riccardo Valdagni.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2017.
300			_aX, 293 p. 63 illus., 40 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aBiology and pathophysiology of bone metastases -- Markers of bone turnover -- Bone homing and metastasis -- Markers of prostate cancer -- Circulating cells -- Radiological assessment of bone metastases -- Nuclear Medicine: bone target imaging -- Nuclear Medicine: cancer and receptor target imaging -- Hormonal therapy -- Chemotherapy -- Combinations of hormonal therapy and chemotherapy -- Surgery -- Radiotherapy -- Bone-targeted agents -- Bone seeking radionuclide for therapy -- New frontiers in treatments -- Approaches for the assessment of response to therapies -- From Symptom control to pain palliation -- Economic impact of prostate cancer bone metastases -- Multidisciplinary approach. .
520			_aThis book presents up-to-date information on one of the hottest topics in prostate cancer, namely bone metastases. The most recent developments with respect to biology, pathology, diagnosis, and treatment are described, providing readers with an excellent understanding of the mechanisms of metastasis formation, the characteristics of metastases, their aggressiveness, and prognostic factors for treatment response. The coverage includes discussion of all of the best available options (laboratory, radiology, and nuclear medicine) for achieving early diagnosis and both established and novel therapeutic approaches. Detailed information is provided on hormonal manipulations, bone-targeted agents, vaccines, taxanes, and other treatments that are enriching the therapeutic armamentarium. The editors can be considered leaders in the field, with great experience in diagnostic and clinical oncology and research, and the authors are experts in diverse specialties. This ensures a multidisciplinary approach, mirroring the current situation in which treatment in patients with bone metastases is undertaken by a team of specialists and health professionals in a variety of fields.
650		0	_aMedicine.
650		0	_aNuclear medicine.
650		0	_aRadiotherapy.
650		0	_aOncology.
650		0	_aOrthopedics.
650		0	_aPathology.
650		0	_aUrology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aOncology.
650	2	4	_aUrology.
650	2	4	_aNuclear medicine.
650	2	4	_aRadiotherapy.
650	2	4	_aOrthopedics.
650	2	4	_aPathology.
700	1		_aBertoldo, Francesco. _eeditor.
700	1		_aBoccardo, Francesco. _eeditor.
700	1		_aBombardieri, Emilio. _eeditor.
700	1		_aEvangelista, Laura. _eeditor.
700	1		_aValdagni, Riccardo. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783319423265
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-319-42327-2
912			_aZDB-2-SME
999			_c1041 _d1041