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008 170315s2017 gw | s |||| 0|eng d
020 _a9783319475073
_9978-3-319-47507-3
024 7 _a10.1007/978-3-319-47507-3
_2doi
035 _a(DE-He213)978-3-319-47507-3
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
245 1 0 _aBone Morphogenetic Proteins: Systems Biology Regulators
_h[electronic resource] /
_cedited by Slobodan Vukicevic, Kuber T. Sampath.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2017.
300 _aXII, 445 p. 43 illus., 32 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aProgress in Inflammation Research
505 0 _aIntroduction -- BMPs: Historic and Future Perspectives -- BMP – Biology -- BMPs in Development -- BMP signaling -- BMP Antagonists - Biology -- BMP and BMP Antagonists - Structure and Function -- BMPs in Orthopaedic Medicine: Promises and Challenges -- BMP6 and Bone Repair -- BMPs in Dental Medicine: Promises and Challenges -- BMPs in Spine -- BMPs in Articular Joints -- BMP Signaling & FOP -- BMP-7 Biology and its Therapeutic Utility for Chronic Kidney Diseases -- BMPs in Inflammation -- BMPs and Angiogenesis -- BMP Signaling in Iron Homeostasis -- BMP Signaling in Pulmonary Arterial Hypertension -- BMP Signaling and Cancer -- BMP Biology in Rare Diseases.
520 _aThis book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit flies to mammals and are responsible for the formation of practically every organ during embryo development and involved in adult tissue injury and repair. BMPs establish their extracellular gradient by interacting with their respective antagonists and regulate their function through SMAD-dependent down-stream signaling effector genes. This volume is aimed at scientists and professionals dealing with metabolic disorders, nutrition, systems biology diseases, rare musculoskeletal conditions, and disorders related to iron metabolism, including anemia of chronic disease, hereditary hemochromatosis and beta thalassemia.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aProteins.
650 0 _aCytokines.
650 0 _aGrowth factors.
650 0 _aSystems biology.
650 0 _aCell biology.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
650 2 4 _aCell biology.
650 2 4 _aCytokines and Growth Factors.
650 2 4 _aProtein Science.
650 2 4 _aSystems biology.
700 1 _aVukicevic, Slobodan.
_eeditor.
700 1 _aSampath, Kuber T.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319475059
830 0 _aProgress in Inflammation Research
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-47507-3
912 _aZDB-2-SME
999 _c1042
_d1042