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007 cr nn 008mamaa
008 170904s2017 gw | s |||| 0|eng d
020 _a9783319597867
_9978-3-319-59786-7
024 7 _a10.1007/978-3-319-59786-7
_2doi
035 _a(DE-He213)978-3-319-59786-7
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
245 1 0 _aDNA and Histone Methylation as Cancer Targets
_h[electronic resource] /
_cedited by Atsushi Kaneda, Yu-ichi Tsukada.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Humana Press,
_c2017.
300 _aVIII, 624 p. 91 illus., 81 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCancer Drug Discovery and Development,
_x2196-9906
505 0 _aDNA and histone methylation in epigenetics -- The molecular basis of DNA methylation -- The molecular basis of DNA demethylation -- DNA methylation changes in cancer -- Misregulation of DNA methylation regulators in cancer -- The molecular basis of histone methylation -- The molecular basis of histone demethylation -- Misregulation of histone methylation regulators in cancer -- Other histone modifications -- DNA methylation and dysregulation of miRNA in cancer -- Genomic imprinting syndromes and cancer -- DNA and Histone Methylation in Brain Cancer -- DNA and Histone Methylation in Gastric Cancer -- DNA and Histone Methylation in Hematopoietic malignancy -- DNA and Histone methylation in Lung cancer -- DNA and Histone Methylation in Liver Cancer -- DNA and Histone Methylation in Colon Cancer -- DNA and histone methylation in prostate cancer -- DNA and histone modifications in cancer diagnosis -- DNA and histone modifications in cancer therapy -- Future perspective of DNA and histone methylation as cancer targets.
520 _aThis book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.
650 0 _aMedicine.
650 0 _aCancer research.
650 1 4 _aBiomedicine.
650 2 4 _aCancer research.
700 1 _aKaneda, Atsushi.
_eeditor.
700 1 _aTsukada, Yu-ichi.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319597843
830 0 _aCancer Drug Discovery and Development,
_x2196-9906
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-59786-7
912 _aZDB-2-SME
999 _c1945
_d1945