000			04067nam a22004935i 4500
001			60096
005			20200226102358.0
007			cr nn 008mamaa
008			161210s2017 gw | s |||| 0|eng d
020			_a9783319426327 _9978-3-319-42632-7
024	7		_a10.1007/978-3-319-42632-7 _2doi
035			_a(DE-He213)978-3-319-42632-7
050		4	_aRD651-678
072		7	_aMNK _2bicssc
072		7	_aMED085000 _2bisacsh
072		7	_aMED062000 _2bisacsh
082	0	4	_a616.994 _223
245	1	0	_aGastrointestinal Stromal Tumors _h[electronic resource] : _bBench to Bedside / _cedited by Charles R. Scoggins, Chandrajit P. Raut, John T. Mullen.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2017.
300			_aXI, 243 p. 61 illus., 24 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aEtiology/Epidemiology -- Pathology -- Molecular Genetics of GIST -- Pediatric GIST/Inheritable Disease -- Natural History -- Radiographic Imaging -- Endoscopic Evaluation -- Prognostic Factors for Localized Disease -- Management of Localized GIST: Non-Surgical Approaches-Surveillance and Endoscopic Resection -- Surgery for Localized GIST -- Minimally Invasive Surgery for GIST -- Neoadjuvant Rx and Surgical Consolidation -- Imatinib -- Management of Locally Advanced GIST -- Prognostic Factors for Advanced GIST -- Concepts of Targeted Therapy Management, Dose Escalation, Tailoring Therapy Based on Specific Mutations, Second Line Therapy -- Surgical Debulking of Metastatic GIST -- Liver Resection/Ablation of Metastatic GIST -- Palliative Care.
520			_aThis textbook provides a comprehensive, state of the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in GIST. The book reviews new data about risk factors for the disease, profiles the new staging system for GIST, highlights our current understanding of genetic mutations that lead to GIST, and provides new perspectives about imaging of GIST tumors. For localized disease, a greater appreciation of organ-sparing approaches and the importance of preservation of gastrointestinal function is discussed in detail, and advances in surgical techniques are highlighted, including minimally invasive surgery. For metastatic disease, the molecular biology of GIST is reviewed in a detailed and understandable manner, including the data that has fostered novel targeted approaches that have revolutionized management. Several landmark trials have been published in the last few years and are placed in context with respect to current management. Integration of surgery and systemic therapy through consolidative approaches has yielded provocative data that promises to further advance the field, and major advances in this domain are also discussed. Gastrointestinal Stromal Tumors: Bench to Bedside will serve as a very useful resource for physicians and researchers dealing with, and interested in, this challenging malignancy. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up to date scientific and clinical information.
650		0	_aMedicine.
650		0	_aGastroenterology.
650		0	_aSurgery.
650		0	_aSurgical oncology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aSurgical oncology.
650	2	4	_aGeneral Surgery.
650	2	4	_aGastroenterology.
700	1		_aScoggins, Charles R. _eeditor.
700	1		_aRaut, Chandrajit P. _eeditor.
700	1		_aMullen, John T. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783319426303
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-319-42632-7
912			_aZDB-2-SME
999			_c2964 _d2964