000			03282nam a22004815i 4500
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007			cr nn 008mamaa
008			171122s2017 gw | s |||| 0|eng d
020			_a9783319503530 _9978-3-319-50353-0
024	7		_a10.1007/978-3-319-50353-0 _2doi
035			_a(DE-He213)978-3-319-50353-0
050		4	_aRL1-803
072		7	_aMJK _2bicssc
072		7	_aMED017000 _2bisacsh
082	0	4	_a616.5 _223
245	1	0	_aAlternatives for Dermal Toxicity Testing _h[electronic resource] / _cedited by Chantra Eskes, Erwin van Vliet, Howard I. Maibach.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2017.
300			_aXX, 592 p. 92 illus., 61 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aIntroduction -- Concepts -- Skin irritation -- Skin corrosion -- Skin sensitization -- UV-induced effects (phototoxicity & photoallergy) -- Skin genotoxicity -- Other exploratory areas of relevance.
520			_aThis book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol, possible adaptations, and challenges and opportunities. The closing section addresses exploratory areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, the use of alternative methods for infections and inflammatory diseases, novel complex skin models, and high-throughput screening techniques. Dermal toxicity is an area in which alternatives to the use of animal testing have already gained scientific, industrial, and regulatory acceptance. Practitioners and researchers alike will find Alternatives for Dermal Toxicity Testing to be an ideal source of reliable, up-to-date information on all aspects of the available test methods and likely future directions.
650		0	_aMedicine.
650		0	_aPharmacology.
650		0	_aDermatology.
650		0	_aAnimal models in research.
650	1	4	_aMedicine & Public Health.
650	2	4	_aDermatology.
650	2	4	_aPharmacology/Toxicology.
650	2	4	_aAnimal Models.
700	1		_aEskes, Chantra. _eeditor.
700	1		_avan Vliet, Erwin. _eeditor.
700	1		_aMaibach, Howard I. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783319503516
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-319-50353-0
912			_aZDB-2-SME
999			_c301 _d301