000 03164nam a22004695i 4500
001 60115
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007 cr nn 008mamaa
008 170102s2017 gw | s |||| 0|eng d
020 _a9783319430638
_9978-3-319-43063-8
024 7 _a10.1007/978-3-319-43063-8
_2doi
035 _a(DE-He213)978-3-319-43063-8
050 4 _aRC254-282
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a616.994
_223
245 1 0 _aImmunotherapy for Gastrointestinal Cancer
_h[electronic resource] /
_cedited by David Kerr, Rebecca Johnson.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2017.
300 _aVIII, 252 p. 23 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aIntroduction to modern immunology -- Cell based therapy – modified cancer cells -- Vaccines for GI cancer -- Antibody delivery of radioactive ‘warheads’ and cytotoxins -- Antibodies which inhibit specific cell pathways -- PD1 and PD1l immune checkpoint inhibitors -- The Role of the JAK/STAT Signaling Pathway in Immunoregulation of Gastrointestinal Cancers -- Hyper mutated colorectal cancer and neoantigen load -- Antibodies which inhibit specific cell pathways, colorectal cancer.
520 _aThis book is about the manipulation of the immune system as a therapeutic approach to gastrointestinal cancer and its clinical applications, exploring therapeutic approaches which might be taken under the broad banner of immunotherapy. Starting by introducing concepts of modern immunology, the clinical applications of immunotherapy are then discussed. The reader will learn about the three broad classes of immune therapeutic agents: cell-based treatment; antibody therapy; cytokine application and the key effector cells and mechanisms which might cause tumour rejection. The reverse side of this equation, the genetic and molecular mechanisms which the tumour can use to escape immune control and regulation, is also discussed. Through reviewing the most up-to-date evidence, this volume provides an overview of the important scientific lessons learned from past failure of immunotherapeutics in the clinic and highlights more positive recent data, coupled to practical guidelines for clinical usage. Written by a team of worldwide experts, this is an indispensable guide for medical oncologists, surgical oncologists, radiation therapists, pharmacists, oncology nurse specialists. .
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aGastroenterology.
650 0 _aOncology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aOncology.
650 2 4 _aImmunology.
650 2 4 _aGastroenterology.
700 1 _aKerr, David.
_eeditor.
700 1 _aJohnson, Rebecca.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319430614
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-43063-8
912 _aZDB-2-SME
999 _c3794
_d3794