000 04282nam a22004935i 4500
001 60041
005 20200226102420.0
007 cr nn 008mamaa
008 161121s2017 gw | s |||| 0|eng d
020 _a9783319408545
_9978-3-319-40854-5
024 7 _a10.1007/978-3-319-40854-5
_2doi
035 _a(DE-He213)978-3-319-40854-5
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
245 1 0 _aIncreasing the Therapeutic Ratio of Radiotherapy
_h[electronic resource] /
_cedited by Philip J. Tofilon, Kevin Camphausen.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Humana Press,
_c2017.
300 _aVIII, 280 p. 41 illus., 34 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCancer Drug Discovery and Development,
_x2196-9906
505 0 _aPart 1. Molecular Targets -- 1. Improving the therapeutic ratio of radiotherapy by targeting the DNA Damage Response -- 2. Receptor Tyrosine Kinases as Targets for Enhancing Tumor Radiosensitivity -- 3. Histone Deacetylase Inhibitors and Tumor Radiosensitization -- 4. Radioprotection as a Method to Enhance the Therapeutic Ratio of Radiotherapy -- Part 2. Microenvironment -- 5. Application of Functional Molecular Imaging in Radiation Oncology -- 6. Remodeling the Irradiated Tumor Microenvironment: The 5th R of Radiobiology? -- 7. Combining Radiotherapy and Immunotherapy: Emerging Preclinical Observations of Lymphocyte Costimulatory and Inhibitory Receptor Modulation -- Part 3. Clinical -- 8. Stereotactic Body Radiation Therapy (SBRT) or Alternative Fractionation Schedules -- 9. Novel Imaging for Treatment Planning or Tumor Response -- 10. Increasing the Therapeutic Efficacy of Radiotherapy Using Nanoparticles -- Index.
520 _aCurrent cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues. The goal of this volume is to describe a number of promising approaches corresponding to each strategy. In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the variety of disparate approaches available for potentially improving the efficacy of radiotherapy, which may then stimulate discussion across disciplines and foster further translational investigations. Although a goal of each chapter will be to highlight advances within an approach, of equal importance will be the delineation of barriers to successful clinical application and how to overcome or minimize such impediments. Along these lines, because therapeutic ratio incorporates both tumor and normal tissue radio response, a point of emphasis will be the mechanistic rationale for selectively modifying tumor (sensitization) or normal cells (protection). Finally, whereas the literature is replete with studies describing potential targets/strategies for increasing the therapeutic ratio for radiotherapy, this book will focus on those supported by in vivo data consistent with impending translational application along with those that are already being evaluated in the clinic.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aDrug resistance.
650 0 _aRadiotherapy.
650 1 4 _aBiomedicine.
650 2 4 _aCancer research.
650 2 4 _aRadiotherapy.
650 2 4 _aDrug resistance.
700 1 _aTofilon, Philip J.
_eeditor.
700 1 _aCamphausen, Kevin.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319408521
830 0 _aCancer Drug Discovery and Development,
_x2196-9906
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-40854-5
912 _aZDB-2-SME
999 _c3810
_d3810