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008 161112s2017 gw | s |||| 0|eng d
020 _a9783319460079
_9978-3-319-46007-9
024 7 _a10.1007/978-3-319-46007-9
_2doi
035 _a(DE-He213)978-3-319-46007-9
050 4 _aRC705-779
072 7 _aMJL
_2bicssc
072 7 _aMED079000
_2bisacsh
082 0 4 _a616.2
_223
100 1 _aPelaia, Girolamo.
_eauthor.
245 1 0 _aAsthma: Targeted Biological Therapies
_h[electronic resource] /
_cby Girolamo Pelaia, Alessandro Vatrella, Rosario Maselli.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2017.
300 _aVI, 99 p. 11 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
520 _aThis book focuses on the fundamentals of the use of biologics in asthma, describing the rationale, principles, mechanisms of action, and indications. It offers an excellent balance between basic science and the analysis of clinical trials, updating readers with new developments that are changing the global scenario for targeted biological anti-asthma therapies, especially with regard to more severe disease. A range of therapies are considered, from the humanized monoclonal anti-IgE antibody omalizumab, widely approved as add-on treatment for inadequately controlled disease, through to emerging biologics for which evidence supportive of efficacy is accumulating, including anti-IL-5, anti-IL-4, and anti-IL-13 therapies. One aspect to emerge is the variability in individual response, which suggests a need for characterization of different asthma subtypes to permit the effective implementation of phenotype-targeted treatments. This book will be of interest for pulmonologists, clinical immunologists, and physicians seeking sound information on these therapies, but also for scientists and pharmacologists wishing to enhance their knowledge of the therapeutic implications of the cellular and molecular mechanisms that underlie severe, uncontrolled asthma.
650 0 _aMedicine.
650 0 _aPharmacology.
650 0 _aAllergy.
650 0 _aGeneral practice (Medicine).
650 0 _aRespiratory organs
_xDiseases.
650 0 _aPediatrics.
650 1 4 _aMedicine & Public Health.
650 2 4 _aPneumology/Respiratory System.
650 2 4 _aAllergology.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aGeneral Practice / Family Medicine.
650 2 4 _aPediatrics.
700 1 _aVatrella, Alessandro.
_eauthor.
700 1 _aMaselli, Rosario.
_eauthor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319460055
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-46007-9
912 _aZDB-2-SME
999 _c474
_d474