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007			cr nn 008mamaa
008			170612s2017 gw | s |||| 0|eng d
020			_a9783319523545 _9978-3-319-52354-5
024	7		_a10.1007/978-3-319-52354-5 _2doi
035			_a(DE-He213)978-3-319-52354-5
050		4	_aQR185.8.C95
072		7	_aPSF _2bicssc
072		7	_aSCI007000 _2bisacsh
072		7	_aSCI017000 _2bisacsh
082	0	4	_a572.6 _223
245	1	0	_aMIF Family Cytokines in Innate Immunity and Homeostasis _h[electronic resource] / _cedited by Richard Bucala, Jürgen Bernhagen.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2017.
300			_aVIII, 246 p. 37 illus., 25 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aProgress in Inflammation Research
505	0		_aMIF and CD74-dependent Mechanisms -- HSP90-stabilized MIF in Oncogenesis and Cell Growth Control- CD74, MIF, and Breast Tumorigenesis: Insights from Recent Large-scale Tumor Genomics and Proteomics Studies -- MIF-dependent Regulation of Monocyte/Macrophage Polarization -- Advances in understanding the role of MIF in the pathogenesis of autoimmune diseases -- Role of MIF in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis -- Role of MIF in Hepatic Inflammatory Diseases and Fibrosis -- MIF and Pulmonary Disease -- MIF Mediates Pelvic Inflammation and Pain -- MIF Family Proteins in Cardiac Ischemia / Reperfusion Injury -- The MIF-CD74 Inflammatory Axis in Alphaviral Infection -- MIF in Eosinophilic Inflammation -- The Role of MIF in Parasitic Infections -- Parasite MIF Orthologs.
520			_aThe role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses. MIF’s molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized. MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.
650		0	_aLife sciences.
650		0	_aImmunology.
650		0	_aInfectious diseases.
650		0	_aCytokines.
650		0	_aGrowth factors.
650		0	_aCell biology.
650	1	4	_aLife sciences.
650	2	4	_aCytokines and Growth Factors.
650	2	4	_aImmunology.
650	2	4	_aInfectious diseases.
650	2	4	_aCell biology.
700	1		_aBucala, Richard. _eeditor.
700	1		_aBernhagen, Jürgen. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783319523521
830		0	_aProgress in Inflammation Research
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-319-52354-5
912			_aZDB-2-SME
999			_c5317 _d5317