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008 170221s2017 si | s |||| 0|eng d
020 _a9789811027116
_9978-981-10-2711-6
024 7 _a10.1007/978-981-10-2711-6
_2doi
035 _a(DE-He213)978-981-10-2711-6
050 4 _aRC346-429.2
072 7 _aMJN
_2bicssc
072 7 _aMED056000
_2bisacsh
082 0 4 _a616.8
_223
245 1 0 _aMoyamoya Disease Explored Through RNF213
_h[electronic resource] :
_bGenetics, Molecular Pathology, and Clinical Sciences /
_cedited by Akio Koizumi, Kazuhiro Nagata, Kiyohiro Houkin, Teiji Tominaga, Susumu Miyamoto, Shigeo Kure, Elizabeth Tournier-Lasserve.
264 1 _aSingapore :
_bSpringer Singapore :
_bImprint: Springer,
_c2017.
300 _aVIII, 185 p. 36 illus., 22 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Environmental Health and Preventive Medicine,
_x2364-8333
505 0 _aPart I: Prologue -- 1. A prologue to moyamoya disease and RNF213 -- 2. Concept of moyamoya Disease -- Part II: Genetic Epidemiology -- 3. Molecular Epidemiology in East Asian Countries and in the World -- Part III: Biochemistry, Function and Molecular Pathology -- 4. Molecular Biology of Mysterin/RNF213 -- 5. Physiological Role of Mysterin/RNF213 in Zebrafish -- 6. Pathological Investigation on RNF213: Animal Models Knockout and Transgenic Mice in Diabetes and Signal Transduction -- 7. Pathological Investigation on RNF213: Animal Models of Rnf213-knockout and Knock-in Mice -- 8. RNF213 and Circulating Factors in Patients with Moyamoya Disease -- 9. Genetics of Moyamoya beyond RNF213. Monogenic Moyamoya Syndromes -- Part IV: Clinical Management 10. Natural History and Long-term Clinical Outcome after Conservative and Surgical Management -- 11. Significance of RNF213 in Clinical Management in Japan -- 12. Significance of RNF213 in Clinical Management in China -- 13. The Different Forms of Moyamoya Disease and Their Clinical Management -- 14. Vascular Diseases Attributable to RNF213 Other than Moyamoya Disease -- Part V: Epilogue -- Future Clinical Perspectives on RNF213 in Moyamoya Disease.
520 _aThis book presents the latest findings on biological, epidemiological, and clinical investigations of RNF213, which is thought to be involved in many biological processes and plays a key role in cerebro- and cardiovascular disease . By discussing the epidemiology and genetic epidemiology of the disease with a particular focus on the molecular function of RNF213, research using animal models, diagnosis, therapy and clinical management around the world, this work makes a valuable contribution to the study of the disease. Moyamoya Disease Explored Through RNF213 is an indispensable resource for both beginning and experienced researchers, pediatricians, neurologists, and neurosurgeons who are seeking comprehensive information on adult and childhood stroke.
650 0 _aMedicine.
650 0 _aPublic health.
650 0 _aNeurology.
650 0 _aNeurosurgery.
650 1 4 _aMedicine & Public Health.
650 2 4 _aNeurology.
650 2 4 _aNeurosurgery.
650 2 4 _aPublic health.
700 1 _aKoizumi, Akio.
_eeditor.
700 1 _aNagata, Kazuhiro.
_eeditor.
700 1 _aHoukin, Kiyohiro.
_eeditor.
700 1 _aTominaga, Teiji.
_eeditor.
700 1 _aMiyamoto, Susumu.
_eeditor.
700 1 _aKure, Shigeo.
_eeditor.
700 1 _aTournier-Lasserve, Elizabeth.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789811027109
830 0 _aCurrent Topics in Environmental Health and Preventive Medicine,
_x2364-8333
856 4 0 _uhttp://dx.doi.org/10.1007/978-981-10-2711-6
912 _aZDB-2-SME
999 _c5529
_d5529