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020 _a9783319422527
_9978-3-319-42252-7
024 7 _a10.1007/978-3-319-42252-7
_2doi
035 _a(DE-He213)978-3-319-42252-7
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
245 1 0 _aNext-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases
_h[electronic resource] /
_cedited by Paola Mina-Osorio.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2017.
300 _aXI, 202 p. 8 illus., 6 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aProgress in Inflammation Research
505 0 _aPreface -- Targeted drug delivery -- I. Bispecific antibodies -- II. Targeting neovessels with NGR peptides -- Genomic-based drugs -- III. Micro-RNA/aptamers -- Nanomedicine -- IV. Exosomes -- V. Microparticles -- Cross-functional targets -- VI. Metabolic targets in inflammation -- VII. Targeting gut microbiome-immune system interactions -- VIII. Targeting the nervous system as an add on therapy for autoinflammatory conditions -- Biomarkers -- IX. Biomarkers in drug discovery -- Other therapies -- X. Stem cell therapy in the treatment of rheumatic disease and application in the treatment of systemic lupus erythematosus.
520 _aAs our understanding of immune mediated chronic inflammatory diseases (IMIDs) grows, it becomes more and more clear that these conditions result from the convergence of a multitude of pathogenic mechanisms whose relative individual contribution is different in different patient subsets. Promising new technologies have been conceived that address the hypotheses that targeting multiple pathways simultaneously, selectively delivering therapeutics to areas of inflammation and/or resetting the immune system, could take efficacy to new levels. However, we have long waited for the arrival of some of these technologies to the bedside, or even far enough in the drug development process in spite of the initial enthusiasm. Some of the examples covered in this book include bispecific antibodies and genomic medicines, microparticles and targeted delivery of drugs to inflamed vasculature. Most published reviews and book chapters on novel therapies for inflammatory diseases describe positive attributes of molecules or technologies under investigation and the rationale for developing them into therapeutics. The originality and potential value of this book is not in the description of these targets or technologies from the point of view of their structure or mechanism of action exclusively, but rather, in making an effort to critically address the question of what is needed to move these technologies into the clinic. Has the technology not made it past the preclinical stage and why? Has it already been tested in humans and failed? What are the potential reasons behind those failures? What do experts in each field believe can be done better to increase the probabilities of success? In addition, the authors address the competitive landscape and summarize clinical studies that have failed in the respective area. They talk about the patient populations that would be required for the successful conduction of a clinical trial to test certain molecules, and they proactively share their views regarding both the potential and the drawbacks of targets or methodologies.
650 0 _aMedicine.
650 0 _aPharmacy.
650 0 _aGene therapy.
650 0 _aImmunology.
650 0 _aPharmaceutical technology.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
650 2 4 _aPharmaceutical Sciences/Technology.
650 2 4 _aGene therapy.
650 2 4 _aPharmacy.
700 1 _aMina-Osorio, Paola.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319422510
830 0 _aProgress in Inflammation Research
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-42252-7
912 _aZDB-2-SME
999 _c5766
_d5766