000			03437nam a22004695i 4500
001			60543
005			20200226102524.0
007			cr nn 008mamaa
008			170325s2017 gw | s |||| 0|eng d
020			_a9783662539941 _9978-3-662-53994-1
024	7		_a10.1007/978-3-662-53994-1 _2doi
035			_a(DE-He213)978-3-662-53994-1
050		4	_aRK1-715
072		7	_aMMD _2bicssc
072		7	_aMED016000 _2bisacsh
082	0	4	_a617.6 _223
245	1	0	_aOrofacial Pain Biomarkers _h[electronic resource] / _cedited by Jean-Paul Goulet, Ana Miriam Velly.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2017.
300			_aX, 155 p. 9 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aBackground: Chronic Orofacial Pain Conditions -- Neurobiologic Mechanisms of Chronic Orofacial Pain -- Biomarkers – Role for Diagnosis, Treatment and Prognosis of Orofacial Pain -- Methodology: Saliva and Serum Biomarkers -- The Search for Pain Biomarkers -- Orofacial Pain Biomarkers: Contribution of Animal Studies -- Masticatory Muscle Pain Biomarkers and Biochemical Fingerprint of Myofascial Trigger Points -- Temporomandibular Joint Pain Biomarkers -- Genetic Biomarkers and Temporomandibular Pain Disorders -- Neurophysiologic and Neuropathologic Biomarkers in Neuropathic Face Pain -- Biomarkers of Autonomic System Involvement in Trigeminal Face Pain -- Immune System and the Modulation of Cytokines Biomarkers -- New Perspectives: Future Studies, Limitation, Clinical Implication -- Conclusion.
520			_aThis book provides up-to-date information on all aspects of orofacial pain biomarkers. It opens by presenting background information on clinical phenotypes and the neurobiological substrates underlying chronic orofacial pain and by explaining the potential role of biomarkers in the diagnosis, prognostic evaluation, and treatment of orofacial pain. The main section of the book examines the contribution of human and animal studies to the field of biomarkers for orofacial pain and discusses biomarkers for masticatory muscle pain, temporomandibular joint pain, neuropathic face pain, and autonomic nervous system involvement in trigeminal facial pain. The potential impacts of the immune system on orofacial pain biomarkers and candidate gene phenotypes with possible links to chronic orofacial pain conditions are also addressed, and differences and similarities between saliva and serum biomarkers for pain are explained as well. The final section covers research-related issues in assessment methods and statistical analyses used in evaluating biomarkers, identifies future challenges and suggests new directions in the field.
650		0	_aDentistry.
650		0	_aPain medicine.
650		0	_aOral surgery.
650		0	_aMaxillofacial surgery.
650	1	4	_aDentistry.
650	2	4	_aDentistry.
650	2	4	_aOral and Maxillofacial Surgery.
650	2	4	_aPain medicine.
700	1		_aGoulet, Jean-Paul. _eeditor.
700	1		_aVelly, Ana Miriam. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783662539927
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-662-53994-1
912			_aZDB-2-SME
999			_c6197 _d6197