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008 170802s2017 gw | s |||| 0|eng d
020 _a9783319574240
_9978-3-319-57424-0
024 7 _a10.1007/978-3-319-57424-0
_2doi
035 _a(DE-He213)978-3-319-57424-0
050 4 _aRC254-282
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a616.994
_223
245 1 0 _aPatient-Derived Mouse Models of Cancer
_h[electronic resource] :
_bPatient-Derived Orthotopic Xenografts (PDOX) /
_cedited by Robert M. Hoffman.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Humana Press,
_c2017.
300 _aXVI, 296 p. 60 illus., 50 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMolecular and Translational Medicine,
_x2197-7852
505 0 _aIn memorium: Jorgen Rygaard (1934-2016) Father of patient derived mouse models of cancer and modern cancer research -- The revival of patient-derived mouse models of cancer: way back to the future -- Patient-derived xenograft models for human cancer, The Freiburg experience -- From Ectopic to Orthotopic Tumor Grafting Sites: Evidence for a Critical Role of the Host Tissue Microenvironment for the Actual Expression of the Malignant Phenotype -- The Effects of the Organ Microenvironment on Metastatic-Cell Gene Signatures -- Techniques for surgical orthotopic implantation of human tumors to immunodeficient mice -- The first patient-derived orthotopic xenograft (PDOX) mouse models of cancer: Cancer of the colon, pancreas, lung, breast, ovary, and mesothelioma -- Patient-derived xenograft models of prostate cancer -- Patient-Derived Mouse Models of Sarcoma -- Cervical cancer patient-derived orthotopic xenograft (PDOX) models -- The use of pediatric patient-derived xenografts for identifying novel agents and combinations -- Development of Orthotopic and Spontaneous Metastatic Human Tumor Xenograft Models for Experimental Therapeutics -- Use of patient-derived orthotopic xenografts (PDOX) to evaluate transformative cancer therapeutics -- Fluorescent protein-expressing transgenic nude mice as hosts for patient tumors -- Fluorescence imaging of tumors in human patient-derived orthotopic xenograft (PDOX) mouse models: The iPDOX model -- The use of patient-derived orthotopic xenograft (PDOX) models to develop curative fluorescence-guided surgery of cancer.-Molecular characteristics of patient-derived tumor xenografts: genomic similarity to patient tumors and relevance for biomarker discovery -- Complementarity of patient-derived orthotopic xenografts (PDOX) models and molecular profiling for optimal therapy -- 3D Cell Culture Models -- Why patient derived mouse models need to be orthotopic -- Foreward: The future of patient-derived models of cancer. .
520 _aThis text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications of the models from drug discovery, genome analysis to personalized treatment are also covered. Written by experts in that field, each of these sections address these critical issues. A brief review of the existing literature addressing the particular topic follows in each section. Presently, there is no single source to provide information on technique and uses of mouse models of human patient tumors. Patient-Derived Mouse Models of Cancer will satisfy this need for cancer researchers, oncologists, pharmaceutical and biotechnology industry scientists as well as molecular biologists studying in vivo systems.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aOncology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aOncology.
650 2 4 _aCancer research.
700 1 _aHoffman, Robert M.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319574233
830 0 _aMolecular and Translational Medicine,
_x2197-7852
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-57424-0
912 _aZDB-2-SME
999 _c6331
_d6331