000			03283nam a22004575i 4500
001			60436
005			20200226102528.0
007			cr nn 008mamaa
008			170629s2017 gw | s |||| 0|eng d
020			_a9783319558257 _9978-3-319-55825-7
024	7		_a10.1007/978-3-319-55825-7 _2doi
035			_a(DE-He213)978-3-319-55825-7
050		4	_aRC254-282
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a616.994 _223
245	1	0	_aPatient-Derived Xenograft Models of Human Cancer _h[electronic resource] / _cedited by Yuzhuo Wang, Dong Lin, Peter W. Gout.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Humana Press, _c2017.
300			_aXI, 204 p. 27 illus., 26 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aMolecular and Translational Medicine, _x2197-7852
505	0		_aIntroduction -- History and Evolution of PDX Cancer Models -- Establishment and Characterization of PDX Models -- Methods of Generating PDX Models -- Fidelity and Stability of PDX Models -- Applications of PDX Models -- Studies of Cancer Heterogeneity -- PDX and Cancer Stem Cells -- Modeling Cancer Metastasis -- Modeling Drug Resistance -- PDX and Biomarker Development -- PDX and Preclinical Drug Screening -- Co-clinical Trials and Personalized Cancer Therapy/Precision Medicine -- Epilogue -- Future Perspective.
520			_aThis book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text. Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the current status of the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field.
650		0	_aMedicine.
650		0	_aOncology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aOncology.
700	1		_aWang, Yuzhuo. _eeditor.
700	1		_aLin, Dong. _eeditor.
700	1		_aGout, Peter W. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783319558240
830		0	_aMolecular and Translational Medicine, _x2197-7852
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-319-55825-7
912			_aZDB-2-SME
999			_c6332 _d6332