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008 170522s2017 gw | s |||| 0|eng d
020 _a9783319422022
_9978-3-319-42202-2
024 7 _a10.1007/978-3-319-42202-2
_2doi
035 _a(DE-He213)978-3-319-42202-2
050 4 _aR895-920
072 7 _aMMPH
_2bicssc
072 7 _aMMP
_2bicssc
072 7 _aMED008000
_2bisacsh
082 0 4 _a616.0757
_223
245 1 0 _aSmall Animal Imaging
_h[electronic resource] :
_bBasics and Practical Guide /
_cedited by Fabian Kiessling, Bernd J. Pichler, Peter Hauff.
250 _a2nd ed. 2017.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2017.
300 _aXIX, 875 p. 396 illus., 284 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPart I Role of small animal imaging: Non invasive imaging for supporting basic research -- Non invasive imaging in the pharmaceutical industry -- How to set up a small animal imaging unit -- Significance of non invasive imaging for animal protection -- Animal Models: From zebrafish to non human primates. Part II Study planning and animal preparation: Institutional preconditions for small animal imaging -- Statistical considerations for animal imaging studies -- Animal anesthesia and monitoring -- Drug administration. Part III Imaging modalities and probes: How to choose the right imaging modality -- How to identify suitable Biomarkers -- Concepts in diagnostic probe design -- X-ray and X-ray-CT -- CT contrast agents -- MR contrast agents -- MRS -- Hyperpolarized MRI -- Ultrasound -- Ultrasound contrast agents -- PET and SPECT -- Radiotracer I: Standard tracer -- Radiotracer II: Peptide-based radiopharmaceuticals -- Optical imaging -- Photoacoustic imaging -- Optical probes -- Multimodal imaging and image fusion. Part IV Ex vivo validation methods:Methods for correlation between in vivo small ani-mal images and post mortem data: example brain -- In Vitro Methods for In Vivo Quantitation of PET and SPECT Imaging Probes: Autoradiography and Gamma Counting. Part V: Data postprocessing: Qualitative and quantitative data analysis -- Guidelines for nuclear image analysis -- Kinetic modeling -- Data documentation systems. Part VI: Special applications:Imaging in drug safety Evaluation -- Cell tracking and transplant imaging -- Imaging of metabolic diseases -- Imaging in developmental biology -- Imaging in gynecology research -- Imaging in cardiovascular research -- Imaging in neurology research I: Neuoroncology -- Imaging in neurology research II: Plasticity and cognitive networks -- Imaging in neurology research III: Neurodegenerative diseases -- Neurooptogenetics -- Imaging in oncology research -- Imaging in immunology research -- Imaging of infectious diseases.  .
520 _aThis textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.
650 0 _aMedicine.
650 0 _aLaboratory medicine.
650 0 _aPharmacology.
650 0 _aRadiology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aImaging / Radiology.
650 2 4 _aLaboratory medicine.
650 2 4 _aPharmacology/Toxicology.
700 1 _aKiessling, Fabian.
_eeditor.
700 1 _aPichler, Bernd J.
_eeditor.
700 1 _aHauff, Peter.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319422008
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-42202-2
912 _aZDB-2-SME
999 _c7412
_d7412