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008 170731s2017 ja | s |||| 0|eng d
020 _a9784431544609
_9978-4-431-54460-9
024 7 _a10.1007/978-4-431-54460-9
_2doi
035 _a(DE-He213)978-4-431-54460-9
050 4 _aRC870-923.2
050 4 _aRC875-899.5
072 7 _aMJS
_2bicssc
072 7 _aMED088000
_2bisacsh
082 0 4 _a616.6
_223
100 1 _aItoh, Masahiro.
_eauthor.
245 1 0 _aTesticular Autoimmunity
_h[electronic resource] :
_bA Cause of Male Infertility /
_cby Masahiro Itoh.
264 1 _aTokyo :
_bSpringer Japan :
_bImprint: Springer,
_c2017.
300 _aXVII, 232 p. 54 illus., 43 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aChapter 1            Biological background of testicular autoimmunity -- Chapter 2            Microcircumstance for induction and prevention of testicular autoimmunity -- Chapter 3            Human testicular autoimmunity as a result of breakdown of testicular immune privilege -- Chapter 4            Testicular autoimmunity by immunization with testicular antigens alone in experimental animals -- Chapter 5            Testicular autoimmunity by the systemic treatment with immuno-potentiating agents in experimental animals -- Chapter 6            Testicular autoimmunity by local injury of the testis in experimental animals.-&a mp;n bsp; Chapter 7            Testicular autoimmunity in experimental animals induced by manipulation of the   immune system -- Chapter 8            The future directions of testicular autoimmunity investigation.
520 _aThis book addresses various aspects of testicular autoimmunity. It has long been suspected that testicular autoimmunity could be one of the causes of idiopathic male infertility. However, it is very difficult to estimate the incidence of testicular autoimmunity in men, as most male patients first realize they are infertile when they start trying to conceive a child, and there is a possibility that their testes may already exhibit the end stage of testicular autoimmunity, in which lymphocytic inflammation and immunoglobulin deposition in their testes subsided long ago and only the spermatogenic disorder remains. Therefore, autopsy or biopsy for testicular tissues in men before the end stage of testicular autoimmunity and investigations using testicular autoimmunity model animals are needed to determine the epidemiology of testicular autoimmunity. Accordingly, the book discusses “the immunological fragility of testis” with regard to male infertility, reviewing aut opsy data in men and presenting experimental data using murine models of autoimmune orchitis that has been induced by immunizing with viable syngeneic testicular germ cells alone. Testicular autoimmunity in animals is also discussed.  In summary, the book provides a wealth of valuable information, not only for researchers who are interested in immunologic male infertility, but also for clinical professionals who treat these patients at hospitals.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aReproductive medicine.
650 0 _aUrology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aUrology.
650 2 4 _aReproductive medicine.
650 2 4 _aImmunology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9784431544593
856 4 0 _uhttp://dx.doi.org/10.1007/978-4-431-54460-9
912 _aZDB-2-SME
999 _c8063
_d8063