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020 _a9783319455143
_9978-3-319-45514-3
024 7 _a10.1007/978-3-319-45514-3
_2doi
035 _a(DE-He213)978-3-319-45514-3
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
245 1 4 _aThe Blood Brain Barrier and Inflammation
_h[electronic resource] /
_cedited by Ruth Lyck, Gaby Enzmann.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2017.
300 _aVI, 286 p. 32 illus., 24 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aProgress in Inflammation Research
505 0 _aGeneral Introduction to Barrier Mechanisms in the Central Nervous System -- Topological Aspects of the Blood-brain and Blood cerebrospinal Fluid Barriers and their Relevance in Inflammation Research -- The Contribution of the Extracellular Matrix to the BBB in Steady State and Inflammatory Conditions -- Pathophysiology of the Bloodbrain Barrier in Neuroinflammatory Diseases -- Leakage at Blood-neural Barriers -- Blood-Brain Barrier Transporters and Neuroinflammation: Partners in Neuroprotection and in Pathology -- MicroRNAs in Brain Endothelium and Inflammation -- Blood-Brain Barrier Dysfunction during Central Nervous System Autoimmune Diseases -- Pathways Across the Blood Brain Barrier -- Neuroinflammation in Bacterial Meningitis -- Blood Vessels in the Brain: a Signaling Hub in Brain Tumor Inflammation.
520 _aWithin the central nervous system (CNS) the constantly changing blood stream is separated from the CNS parenchyma by the blood brain barrier (BBB) restricting passage to selected immune cells. Under pathological conditions, however, viruses, bacteria, parasites and autoaggressive immune cells can penetrate the barrier and contribute to CNS inflammation. The BBB actively contributes to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alteration of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential for the development of new drugs to efficiently combat inflammatory diseases of the CNS. This book presents a comprehensive collection of reviews that focus on the role of the BBB. Experts in the field share their insight on structural, topological and functional properties of the BBB. They elaborate on pathophysiological changes of the inflamed BBB such as permeability, transporter proteins and alterations in microRNAs and cytokine profile. Additional chapters on multiple sclerosis and bacterial meningitis provide in depth information on significant neuroinflammatory diseases. The selection is complemented by a review on the current understanding of the BBB as signaling hub in tumor pathogenesis in the brain.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aNeurosciences.
650 0 _aInfectious diseases.
650 0 _aCytokines.
650 0 _aGrowth factors.
650 0 _aCell membranes.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
650 2 4 _aNeurosciences.
650 2 4 _aMembrane Biology.
650 2 4 _aInfectious diseases.
650 2 4 _aCytokines and Growth Factors.
700 1 _aLyck, Ruth.
_eeditor.
700 1 _aEnzmann, Gaby.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319455129
830 0 _aProgress in Inflammation Research
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-45514-3
912 _aZDB-2-SME
999 _c8086
_d8086