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008			161112s2017 xxu| s |||| 0|eng d
020			_a9781597454582 _9978-1-59745-458-2
024	7		_a10.1007/978-1-59745-458-2 _2doi
035			_a(DE-He213)978-1-59745-458-2
050		4	_aRC254-282
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a616.994 _223
245	1	4	_aThe Molecular Basis of Human Cancer _h[electronic resource] / _cedited by William B. Coleman, Gregory J. Tsongalis.
250			_a2nd ed. 2017.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Humana Press, _c2017.
300			_aXIX, 873 p. 217 illus., 120 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aCancer Epidemiology: Incidence and Etiology of Human Neoplasms -- Essential Concepts and Techniques in Molecular Biology -- Cancer Genomics -- Cancer Cytogenetics -- The Epigenetic Basis of Human Cancer -- Cancer Proteomics -- An Overview of Cancer Genes -- Oncogenes and the Initiation and Maintenance of Tumorigenesis -- Positive Mediators of Cell Proliferation in Neoplasia: Growth Factors and Receptors -- Senescence, Apoptosis, and Cancer -- Novel Cancer Therapies Targeting Angiogenesis -- Beyond the Primary Tumor: Progression, Invasion, and Metastasis -- Simple Sequence Mutations -- Single Nucleotide Polymorphisms and Cancer Susceptibility -- Chromosomes and Chromosomal Instability in Human Cancer -- Epigenetic Mechanisms in Cancer Development -- MicroRNAs and Cancer -- Erionite and Asbestos in the Pathogenesis of Human Malignant Mesotheliomas -- Viral Mechanisms in Human Carcinogenesis -- Hormonal Carcinogenesis: The Role of Estrogens -- Sporadic Cancers -- Hereditary Cancer -- Retinoblastoma: Clinical and Molecular Perspectives -- Xeroderma Pigmentosum and the DNA Damage Response to Ultraviolet Light -- Hereditary Colorectal Cancer -- Hereditary Breast and Ovarian Cancer -- The Molecular Basis of Prostate Carcinogenesis -- Molecular Basis of Lung Carcinogenesis -- The Molecular Basis of Skin Carcinogenesis -- The Molecular Biology of Leukemias -- Molecular Mechanisms in Non-Hodgkin Lymphoma -- The Molecular Pathology of Head and Neck Squamous Cell Carcinoma -- Ovarian Cancer -- Molecular Pathology of Bone and Soft Tissue Tumors -- The Molecular Biology of Human Brain Tumors -- Cancer Drug Discovery and Anticancer Drug Development -- Biological Principles and Clinical Application of EGFR Inhibitors in Cancer -- Targeting Oncoproteins for Molecular Cancer Therapy -- Therapeutic Agents that Inhibit Angiogenesis -- Small Molecule Inhibitors -- Molecular Detection and Diagnosis of Cancer -- Gene Therapy in the Treatment of Human Cancer -- Personalized Medicine for the Treatment of Human Cancer.
520			_aThis book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care. The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.
650		0	_aMedicine.
650		0	_aOncology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aOncology.
700	1		_aColeman, William B. _eeditor.
700	1		_aTsongalis, Gregory J. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781934115183
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-59745-458-2
912			_aZDB-2-SME
999			_c8127 _d8127