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020 _a9783319524986
_9978-3-319-52498-6
024 7 _a10.1007/978-3-319-52498-6
_2doi
035 _a(DE-He213)978-3-319-52498-6
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
082 0 4 _a612.8
_223
245 1 0 _aTranslational Anatomy and Cell Biology of Autism Spectrum Disorder
_h[electronic resource] /
_cedited by Michael J. Schmeisser, Tobias M. Boeckers.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2017.
300 _aVIII, 211 p. 17 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Anatomy, Embryology and Cell Biology,
_x0301-5556 ;
_v224
505 0 _aAnatomy and cell biology of autism spectrum disorder: Lessons from human genetics -- Neuroanatomy and neuropathology of autism spectrum disorder in humans -- Modelling autistic neurons with induced pluripotent stem cells -- Modelling autistic features in mice using quantitative genetic approaches -- Behavioural phenotypes and neural circuit dysfunctions in mouse models of autism spectrum disorder -- Cerebellar and striatal pathologies in mouse models of autism spectrum disorder -- The role of neurotrophic factors in mouse models of autism spectrum disorder: focus on Bdnf and Igf-1 -- The role of the oxytocin/arginine vasopressin system in animal models of autism spectrum disorder -- Extracerebral dysfunction in animal models of autism spectrum disorder -- Genetic and pharmacological reversibility of phenotypes in mouse models of autism spectrum disorder.
520 _aAutism spectrum disorder (ASD) affects approximately 1 % of the human population and is characterized by a core symptomatology including deficits in social interaction and repetitive patterns of behaviour plus various co-morbidities. Although a lot of progress has been made to uncover underlying causes and mechanisms throughout the last decade, we are still at the very beginning to understand this enormously complex neurodevelopmental condition. This special volume is focused on translational anatomy and cell biology of ASD. International experts from the field including several members of the EU-AIMS initiative launched by the European Union to develop novel treatments for ASD have contributed chapters on several topics covering all crucial aspects of translational ASD research with a special emphasis on ASD model systems including stem cells and animals. Primary objective is to clarify how anatomical and cell biological phenotypes of ASD will help to translate basic mechanisms to clinical practice and to efficiently treat affected individuals in the near future.
650 0 _aMedicine.
650 0 _aNeurosciences.
650 0 _aPsychiatry.
650 0 _aCell biology.
650 1 4 _aBiomedicine.
650 2 4 _aNeurosciences.
650 2 4 _aPsychiatry.
650 2 4 _aCell biology.
700 1 _aSchmeisser, Michael J.
_eeditor.
700 1 _aBoeckers, Tobias M.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319524962
830 0 _aAdvances in Anatomy, Embryology and Cell Biology,
_x0301-5556 ;
_v224
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-52498-6
912 _aZDB-2-SME
999 _c8319
_d8319