000			03117nam a22004455i 4500
001			60002
005			20200226102257.0
007			cr nn 008mamaa
008			170802s2017 gw | s |||| 0|eng d
020			_a9783319391472 _9978-3-319-39147-2
024	7		_a10.1007/978-3-319-39147-2 _2doi
035			_a(DE-He213)978-3-319-39147-2
050		4	_aRB1-214
072		7	_aMMF _2bicssc
072		7	_aMED067000 _2bisacsh
082	0	4	_a616.07 _223
245	1	0	_aBiomarkers of the Tumor Microenvironment _h[electronic resource] : _bBasic Studies and Practical Applications / _cedited by Lars A. Akslen, Randolph S. Watnick.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2017.
300			_aXVII, 534 p. 52 illus., 51 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aMarkers of tumor-vascular interactions -- Extracellular matrix, especially integrins, importance for tumor progression -- Role of Axl for epithelial-mesenchymal transition and tumor spread -- Models of tumour progression in prostate cancer -- Biomarkers of tumor progression in malignant melanoma -- Biomarker signatures and tumor progress in breast cancer -- Biomarker panels and contemporary practice in clinical trials of targeted treatment -- Role of prosaposin in niche regulation and metastatic spread -- Regulators of microenvironment and metastases in prostate cancer -- Semaphorins and angiogenesis -- Heterogeneity of angiogenesis phenotypes -- Biology of metastatic niches -- Lymphangiogenesis and tumor progress -- Extracellular matrix -- Paracrine signalling and tumor progress -- Cancer associated fibroblasts -- Tumor immunology -- Interleukins and inflammatory programs in tumor progress -- Global gene expression signatures of the tumor microenvironment -- Microarray analysis of the tumour microenvironment -- Studies of the tumor microenvironment.
520			_aThis book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms of how biomarkers are increasingly included in therapy protocols, will also be discussed. Biomarkers of the Tumour Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in the cancer field, and also cancer researchers from other backgrounds, especially those using morphology techniques and models focusing on cross-talk between different cell types in tumors.
650		0	_aMedicine.
650		0	_aCancer research.
650		0	_aPathology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aPathology.
650	2	4	_aCancer research.
700	1		_aAkslen, Lars A. _eeditor.
700	1		_aWatnick, Randolph S. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783319391458
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-319-39147-2
912			_aZDB-2-SME
999			_c947 _d947